Pannexin 3 deletion reduces fat accumulation and inflammation in a sex-specific manner
C. B. Wakefield, V. R. Lee, D. Johnston, P. Boroumand, N. J. Pillon, S. Sayedyahossein, B. L. O'Donnell, J. Tang, R. E. Sanchez-Pupo, K. J. Barr, R. Gros, L. E. Flynn, N. Borradaile, A. Klip, F. Beier, S. Penuela
This study shows that PANX3 deletion reduces fat mass and inflammation in male mice but not females, with male KOs having fewer adipocytes and lower inflammatory gene expression.
bioRxiv · May 4, 2021Physiology