Chronic infection control relies on T cells with lower foreign antigen binding strength generated by N-nucleotide diversity
H. Jamaleddine, D. Rogers, G. Perreault, J. N. Mandl, A. Khadra
The paper shows that TdT-mediated TCR diversity, characterized by lower-affinity T cells, aids in controlling chronic infections but not acute ones.
bioRxiv · Jun 26, 2022Immunology