Author

J. N. Mandl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Assay:CITE-seq· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1

Frequent Co-Authors

D. Rogers· 3 shared J. Textor· 3 shared I. M. N. Wortel· 2 shared A. Fähnrich· 1 shared A. J. Martins· 1 shared A. Khadra· 1 shared A. Sood· 1 shared C. Kesmir· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersImmunology

D. Rogers

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Author profile →

4 papers

Recent·Most cited

Machine learning analysis of the T cell receptor repertoire identifies sequence features that predict self-reactivity

J. Textor, F. Buytenhuijs, D. Rogers, E. Mallet Gauthier, S. Sultan, I. M. N. Wortel, K. Kalies, A. Fähnrich, R. Pagel, H. Melichar, J. Westermann, J. N. Mandl

The paper uses machine learning to identify TCR sequence features predicting self-reactivity, finding that n-nucleotide additions and acidic amino acids reduce self-reactivity.

bioRxiv · Nov 23, 2022Immunology

Chronic infection control relies on T cells with lower foreign antigen binding strength generated by N-nucleotide diversity

H. Jamaleddine, D. Rogers, G. Perreault, J. N. Mandl, A. Khadra

The paper shows that TdT-mediated TCR diversity, characterized by lower-affinity T cells, aids in controlling chronic infections but not acute ones.

bioRxiv · Jun 26, 2022Immunology

Pre-existing chromatin accessibility and gene expression differences among naïve CD4+ T cells influence effector potential

D. Rogers, A. Sood, H. Wang, J. J. P. van Beek, T. J. Rademaker, P. Artusa, C. Schneider, C. Shen, D. C. Wong, M.-E. Lebel, S. A. Condotta, M. J. Richer, A. J. Martins, J. S. Tsang, L. Barreiro, , J. N. Mandl

The paper shows pre-existing transcriptional and chromatin differences in naive CD4+ T cells influence their effector lineage potential.

bioRxiv · Apr 21, 2021Immunology

Negative T cell selection on non-random peptides promotes robust self-nonself discrimination

I. M. N. Wortel, C. Kesmir, R. J. De Boer, J. N. Mandl, J. Textor

The paper shows that negative T cell selection on non-random peptides enables robust self-nonself discrimination despite incomplete silencing of self-reactive cells.

bioRxiv · Apr 5, 2019Immunology