The splicing isoform Foxpdelta2 releases the autoinhibitory conformation and differentially regulates tTregs and pTregs homeostasis
G. Qianchong, Z. Xiufeng, G. Jie, X. Wei, Z. Jianhua, Z. Wei, Z. Fuping, H. Baidong, Z. Xuyu
This study shows that the Foxp3{Delta}2 isoform, generated by alternative splicing, alters Treg function by enhancing DNA binding and affecting homeostasis in different Treg subsets.
bioRxiv · Jan 9, 2023Immunology