Exploiting allele-specific transcriptional effects of subclonal copy number alterations for genotype-phenotype mapping in cancer cell populations
H. Shi, M. J. Williams, G. Satas, A. C. Weiner, A. McPherson, S. P. Shah
This paper develops TreeAlign to map subclonal copy number alterations to transcriptional phenotypes in cancer cells, showing improved accuracy in clone-specific gene expression analysis.
bioRxiv · Jan 10, 2023 · PreprintCancer Biology