M. J. Williams

Single-cell DNA replication dynamics in genomically unstable cancers

The paper develops a method to infer DNA replication states from single-cell sequencing and analyzes replication dynamics in aneuploid cancers, finding correlations between replication timing and copy number changes.

Exploiting allele-specific transcriptional effects of subclonal copy number alterations for genotype-phenotype mapping in cancer cell populations

This paper develops TreeAlign to map subclonal copy number alterations to transcriptional phenotypes in cancer cells, showing improved accuracy in clone-specific gene expression analysis.

Adaptation to ex vivo culture drives human haematopoietic stem cell loss of repopulation capacity in a cell cycle independent manner

This study shows that human LT-HSC loss of repopulation capacity during ex vivo culture occurs rapidly after adaptation, independent of cell cycle progression.

High-performance Flexible Microelectrode Array with PEDOT:PSS Coated 3D Micro-cones for Electromyographic Recording

This paper develops a flexible 3D microelectrode array with PEDOT:PSS coating for high-quality EMG recording, achieving high SNR and improved impedance.

Immune and malignant cell phenotypes of ovarian cancer are determined by distinct mutational processes

This study identifies distinct immune and malignant cell phenotypes in ovarian cancer linked to specific mutational processes and anatomic sites.

Clonal dynamics of normal hepatocyte expansions in homeostatic human livers and their association with the biliary epithelium

The paper studies clonal hepatocyte expansions in normal human livers, finding a periportal progenitor niche and slow clonal expansion dynamics.

Evolutionary tracking of cancer haplotypes at single-cell resolution

The paper tracks cancer haplotypes at single-cell resolution, revealing allele-specific alterations and their role in structural variation evolution in human tumors.

The impact of mutational processes on structural genomic plasticity in cancer cells

The paper analyzes structural genomic variations in cancer cells to understand how mutational processes influence cell-to-cell genomic diversity and tumor evolution.

Evolutionary dynamics of neoantigens in growing tumours

This study develops a mathematical model of neoantigen evolution in tumors and validates it with colorectal cancer data, showing how negative selection shapes tumor immunogenotype and clonality.

A low-cost, rapidly integrated debubbler (RID) module for microfluidic cell culture applications

The paper introduces a low-cost debubbler module for microfluidic systems to remove air bubbles efficiently, ensuring undisturbed flow for cell culture applications.

Measuring single cell divisions in human cancers from multi-region sequencing data

This study measures single-cell division rates and survival in human cancers using multi-region sequencing data, revealing per-cell mutation and survival rates across different cancer types and healthy tissues.

Quantification of subclonal selection in cancer from bulk sequencing data

This study quantifies subclonal selection in cancer using bulk sequencing data to determine mutation rates, selective advantages, and subclone emergence times in gastric and lung cancers.