Author

A. C. Weiner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 5 Organism:human· 5 Approach:statistical model· 5 Research Focus:clustering· 4 Approach:deep learning· 3 Research Focus:gene regulatory network inference· 3 Assay:whole-genome sequencing· 3 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

A. McPherson· 4 shared M. J. Williams· 4 shared S. P. Shah· 4 shared N. Rusk· 3 shared S. Aparicio· 3 shared B. Wang· 2 shared D. Abrams· 2 shared D. Lai· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCancer Biology

A. McPherson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Single-cell DNA replication dynamics in genomically unstable cancers

A. C. Weiner, M. J. Williams, H. Shi, I. Vazquez-Garcia, S. Salehi, N. Rusk, S. Aparicio, S. P. Shah, A. McPherson

The paper develops a method to infer DNA replication states from single-cell sequencing and analyzes replication dynamics in aneuploid cancers, finding correlations between replication timing and copy number changes.

bioRxiv · Apr 10, 2023Cancer Biology

Exploiting allele-specific transcriptional effects of subclonal copy number alterations for genotype-phenotype mapping in cancer cell populations

H. Shi, M. J. Williams, G. Satas, A. C. Weiner, A. McPherson, S. P. Shah

This paper develops TreeAlign to map subclonal copy number alterations to transcriptional phenotypes in cancer cells, showing improved accuracy in clone-specific gene expression analysis.

bioRxiv · Jan 10, 2023 · PreprintCancer Biology

Evolutionary tracking of cancer haplotypes at single-cell resolution

M. J. Williams, T. Funnell, C. O'Flanagan, A. McPherson, S. Salehi, I. Vazquez-Garcia, F. Kabeer, H. Lee, T. Masud, P. Eirew, D. Yap, B. Wang, J. Brimhall, J. Biele, J. Ting, , S. P. Shah

The paper tracks cancer haplotypes at single-cell resolution, revealing allele-specific alterations and their role in structural variation evolution in human tumors.

bioRxiv · Jun 4, 2021 · PreprintCancer Biology

The impact of mutational processes on structural genomic plasticity in cancer cells

T. Funnell, C. H. O'Flanagan, M. J. Williams, A. McPherson, S. McKinney, F. Kabeer, H. Lee, T. Masud, P. Eirew, D. Yap, A. W. Zhang, J. L. P. Lim, B. Wang, J. Brimhall, J. Biele, , S. Aparicio

The paper analyzes structural genomic variations in cancer cells to understand how mutational processes influence cell-to-cell genomic diversity and tumor evolution.

bioRxiv · Jun 3, 2021 · PreprintCancer Biology

Modeling Cell-Specific Dynamics and Regulation of the Common Gamma Chain Cytokines

A. M. Farhat, A. C. Weiner, C. Posner, Z. S. Kim, B. Orcutt-Jahns, S. M. Carlson, A. S. Meyer

The paper builds a dynamical model of common gamma-chain cytokines to predict ligand responses and shows receptor trafficking and tensor factorization are essential for accurate modeling and engineering cell-specific responses.

bioRxiv · Mar 19, 2020Immunology