G. Sella

Down the Penrose stairs: How selection for fewer recombination hotspots maintains their existence

The paper models how PRDM9's role in coupling DSB formation and repair drives the evolution of fewer, stronger recombination hotspots.

The impact of genetic modifiers on variation in germline mutation rates within and among human populations

This paper investigates how genetic modifiers influence variation in germline mutation rates within and among human populations using analytical models and simulations.

Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elements

The paper models purifying selection and selective sweeps in human genetic diversity using 1000 Genomes data, finding background selection explains most diversity variance.

Polygenic adaptation after a sudden change in environment

The paper models polygenic adaptation after a sudden environmental change, showing two phases of allele dynamics and their implications for genetic adaptation.

Life history effects on neutral polymorphism levels of autosomes and sex chromosomes

The paper derives general expressions for life history effects on X-to-autosome diversity ratios, showing they depend on sex-ratio parameters like mutation rates and generation times.

Changes in life history and population size can explain relative neutral diversity levels on X and autosomes in extant human populations

The paper explains differences in X and autosome neutral diversity ratios in humans by considering life history traits and population size changes.