M. Przeworski

Patterns of recombination in snakes reveal a tug of war between PRDM9 and promoter-like features

The study analyzes recombination patterns in corn snakes to show that both PRDM9 and promoter-like features influence recombination, revealing a competitive interaction between these mechanisms.

Down the Penrose stairs: How selection for fewer recombination hotspots maintains their existence

The paper models how PRDM9's role in coupling DSB formation and repair drives the evolution of fewer, stronger recombination hotspots.

Limited role of generation time changes in driving the evolution of mutation spectrum in humans

The paper examines how changes in generation time affect human mutation spectra, finding that such changes cannot fully explain observed mutation patterns, suggesting other factors are involved.

PRDM9 losses in vertebrates are coupled to those of paralogs ZCWPW1 and ZCWPW2

The paper identifies genes coevolving with PRDM9 across vertebrates, suggesting ZCWPW1 and ZCWPW2 as key interactors in meiotic recombination.

A paternal bias in germline mutation is widespread in amniotes and can arise independently of cell divisions

The paper examines paternal bias in germline mutations across 42 amniote species and finds a consistent paternal-to-maternal mutation ratio despite varying gametogenesis and environments.

Mutation saturation for fitness effects at human CpG sites

The paper uses mutation saturation at CpG sites to identify deleterious mutations by analyzing polymorphism absence in large exome datasets.

Population genetics of the coral Acropora millepora: Towards a genomic predictor of bleaching

This study generates a genome assembly for Acropora millepora and identifies genetic predictors of bleaching using genome-wide association analysis.

A comparison of humans and baboons suggests germline mutation rates do not track cell divisions

This paper compares germline mutation rates between humans and baboons, finding similar male mutation bias despite differences in reproductive timing, challenging the cell division hypothesis.

Natural selection interacts with the local recombination rate to shape the evolution of hybrid genomes

The persistence of hybrid ancestry is predictable from local recombination rates in three replicate hybrid populations and in humans.

Identifying genetic variants that affect viability in large cohorts

The paper identifies genetic variants affecting viability by analyzing large cohorts, finding few common variants with large effects on age-specific mortality and sex-specific differences.

Repeated losses of PRDM9-directed recombination despite the conservation of PRDM9 across vertebrates

The paper identifies PRDM9 orthologs across 225 vertebrate species and finds repeated losses of PRDM9-directed recombination despite its conservation, linking complete orthologs to rapid evolution of binding affinity.

Contrasting determinants of mutation rates in germline and soma

The paper compares mutation rate determinants in germline and somatic tissues, finding shared factors but contrasting effects of expression levels on mutation rates in ovaries/testes versus tumors.