Ca2+ Mediates HIF-dependent Upregulation of Aquaporin 1 in Pulmonary Arterial Smooth Muscle Cells
X. Yun, S. Maman, H. JIang, G. Semenza, L. Shimoda
This study shows that in pulmonary arterial smooth muscle cells, HIF upregulates AQP1 protein through Ca2+ elevation rather than direct transcriptional regulation.
bioRxiv · Dec 6, 2021 · PreprintCell Biology