Author

G. W. Donovan

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Biology Disciplines

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Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. J. Friedman· 1 shared E. T. Liechty· 1 shared H. M. Padgette· 1 shared J. M. Fox· 1 shared L. Kramer· 1 shared M. R. Shirts· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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1 shared paperBioengineering

A. J. Friedman

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1 paper

Recent·Most cited

A biophysical rationale for the selective inhibition of PTP1B over TCPTP by nonpolar terpenoids

A. J. Friedman, H. M. Padgette, L. Kramer, E. T. Liechty, G. W. Donovan, J. M. Fox, M. R. Shirts

The paper investigates how nonpolar terpenoids selectively inhibit PTP1B over TCPTP by disrupting conserved allosteric networks, with differences in amino acid conservation at specific sites enabling this selectivity.

bioRxiv · Apr 17, 2023 · PreprintBioengineering