Author

A. J. Friedman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:mechanistic / dynamical model· 3 Research Focus:drug response / drug discovery· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Organism:plant (other)· 1 Assay:protein structure· 1

Frequent Co-Authors

E. T. Liechty· 2 shared M. R. Shirts· 2 shared A. C. Leonard· 1 shared A. Sarkar· 1 shared B. M. Petersen· 1 shared G. W. Donovan· 1 shared H. M. Padgette· 1 shared J. Fox· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBioengineering

E. T. Liechty

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Rationalizing diverse binding mechanisms to the same protein fold: in-sights for ligand recognition and biosensor design

A. C. Leonard, A. J. Friedman, R. Chayer, B. M. Petersen, J. Kaar, M. R. Shirts, T. A. Whitehead

This study analyzes two engineered biosensors based on PYR1 to recognize different ligands, revealing binding mechanisms and computational methods for biosensor design.

bioRxiv · Mar 25, 2024Bioengineering

A biophysical rationale for the selective inhibition of PTP1B over TCPTP by nonpolar terpenoids

A. J. Friedman, H. M. Padgette, L. Kramer, E. T. Liechty, G. W. Donovan, J. M. Fox, M. R. Shirts

The paper investigates how nonpolar terpenoids selectively inhibit PTP1B over TCPTP by disrupting conserved allosteric networks, with differences in amino acid conservation at specific sites enabling this selectivity.

bioRxiv · Apr 17, 2023 · PreprintBioengineering

Allosteric Inhibition of PTP1B by a Nonpolar Terpenoid

A. J. Friedman, E. T. Liechty, L. D. Kramer, A. Sarkar, J. Fox, M. Shirts

This study identifies amorphadiene as a selective allosteric inhibitor of PTP1B, showing it binds to multiple sites on the C-terminus and stabilizes the PTP1B-AD complex.

bioRxiv · May 18, 2022Biochemistry