Spatial immune ecosystems govern therapeutic response in HER2-low breast cancer
Olajumoke Ogunlusi, Soupayan Banerjee, Akshara Singareeka, Stephen Akanbi, Mrinmoy Sarkar, Pritam Dey, Bo Lin, Yingxiang Xu, Tommy Tran, Danielle Fails, Bani Mallick, Gabriela Raso, Debu Tripathy, Tapasree Roy Sarkar
This study uses single-cell spatial transcriptomics to show that dendritic cell states and immune architecture in HER2-low breast cancer influence therapeutic response, with specific immune niches linked to resistance or sensitivity.
bioRxiv · Aug 24, 2026 · PreprintCancer Biology