The histone variant H2A.Z and its chaperone SRCAP are required for RNA polymerase II to access HBV chromatin
Basile Jay, Océane Lopez, Laetitia Gérossier, Nazim Sarica, Gabrielle Pozo, Sabine Gerbal‐Chaloin, Martine Daujat‐Chavanieu, O. Hantz, Christine Neuveut, Joao Diogo Dias
This study identifies H2A.Z and SRCAP as essential for HBV cccDNA transcription by promoting chromatin accessibility and RNA polymerase II recruitment.
bioRxiv · Nov 10, 2025 · PreprintMicrobiology