Author

Sabine Gerbal‐Chaloin

InsermORCID 0000-0002-2549-7899Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Martine Daujat‐ChavanieuiD· 2 shared Alain ChavanieuiD· 1 shared Alberto AneliD· 1 shared Alexandre FavereauxiD· 1 shared Amel Bouzid· 1 shared Ana Bellia Aznar· 1 shared Ananya Sen· 1 shared Anthony R. MartiniD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersMicrobiology

Martine Daujat‐ChavanieuORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Wild-type and mutated beta-catenin differently repress RND3/RHOE expression in hepatocellular carcinoma

Sara Basbous, Sandra Sena, Grégoire Manaud, Camille Dantzer, Véronique Neaud, Léo Piquet, Florence Grise, Frédéric Martins, Christine Varon, Sabine Gerbal‐Chaloin, Alexandre Favereaux, Sabine Colnot, Valérie Lagrée, Clotilde Billottet, Violaine Moreau

This study shows wild-type and mutated beta-catenin differently repress RND3/RHOE expression in hepatocellular carcinoma through distinct mechanisms.

Scientific Reports · Oct 3, 2026Peer-reviewedCancer Biology

The histone variant H2A.Z and its chaperone SRCAP are required for RNA polymerase II to access HBV chromatin

Basile Jay, Océane Lopez, Laetitia Gérossier, Nazim Sarica, Gabrielle Pozo, Sabine Gerbal‐Chaloin, Martine Daujat‐Chavanieu, O. Hantz, Christine Neuveut, Joao Diogo Dias

This study identifies H2A.Z and SRCAP as essential for HBV cccDNA transcription by promoting chromatin accessibility and RNA polymerase II recruitment.

bioRxiv · Nov 10, 2025 · PreprintMicrobiology

Targeting Pregnane X Receptor with a Potent Agonist-Based PROTAC to Delay Colon Cancer Relapse

Lucile Bansard, Guillaume Laconde, Vanessa Delfosse, Tiphaine Huet, Margaux Ayeul, Émilie Rigal, Quentin Donati, Sabine Gerbal‐Chaloin, Martine Daujat‐Chavanieu, Luc Brunel, Baptiste Legrand, Alain Chavanieu, Anthony R. Martin, Julie Pannequin, William Bourguet, , Jean‐Marc Pascussi

This study designs and tests a PXR agonist-based PROTAC (JMV7048) that degrades PXR in cancer cells, reducing chemoresistance and delaying colon cancer relapse.

Oncogenesis · Aug 30, 2025Peer-reviewedCancer Biology

Metabolic rewiring of cancer cells induces metastasis via ERK5 but triggers recognition by NK cells

Sara Zemiti, Steffy Escayg, Benjamin Hay, Amel Bouzid, Catherine Alexia, Carine Jacquard, Noemie Dudzinska, Ananya Sen, Jose Prudenciano, Daouda Abba Moussa, Michael Constantinides, Loïs Coënon, Nerea Allende-Vega, Mauricio Campos‐Mora, Sabine Gerbal‐Chaloin, , Delphine Gitenay

This study shows that metabolic rewiring via fatty acid oxidation promotes cancer metastasis but also enhances NK cell recognition and killing of metastatic cells.

bioRxiv · Aug 26, 2025 · PreprintCancer Biology