Discovery of synthetic lethal interactions from large-scale pan-cancer perturbation screens
Sumana Srivatsa, Hesam Montazeri, Gaia Bianco, Mairene Coto‐Llerena, Mattia Marinucci, Charlotte K.Y. Ng, Salvatore Piscuoglio, Niko Beerenwinkel
This study develops a statistical framework to identify synthetic lethal gene pairs from cancer perturbation screens and validates novel interactions in hepatocellular carcinoma.
Nature Communications · Dec 14, 2022Peer-reviewedBioinformatics