Mairene Coto‐Llerena

This paper introduces SHOCOs, a modular system using patient-derived colorectal tumor organoids and fibroblasts to model tumor microenvironments, showing improved immune response and stromal effects on therapy.

This study uses ribosome profiling to show that steatohepatitis-associated HCC has extensive translational alterations affecting hundreds of genes and revealing novel translated regions.

The paper identifies IFNAR1+ neutrophils as key drivers of chronic inflammation through mitochondrial remodeling and IFN signaling, showing therapeutic potential for targeting IFNAR1.

This study identifies RPL39L as an efficiency factor in cotranslational folding of alpha helical proteins by analyzing its expression, ribosome structure, and impact on translation dynamics.

This study develops a statistical framework to identify synthetic lethal gene pairs from cancer perturbation screens and validates novel interactions in hepatocellular carcinoma.

APSiC identifies novel cancer genes and non-genetic drivers from perturbation screens, revealing context-dependent oncogenic mechanisms and functional roles in specific cancers.