PARP1 promotes replication-independent DNA double-strand break formation after acute DNA-methylation damage
Anne Marie McMahon, Haichao Zhao, Jia Li, Garrett Driscoll, Joshua Matos, Kelly McGhee, J. A. Lyttle, Shan Yan
This study shows PARP1 promotes replication-independent DSB formation after MMS-induced methylation damage through NAD+ consumption and PARylation.
bioRxiv · Jul 10, 2025 · PreprintMolecular Biology