Shan Yan

This study shows PARP1 promotes replication-independent DSB formation after MMS-induced methylation damage through NAD+ consumption and PARylation.

The paper identifies APE1 as a direct recruiter of ATRIP to ssDNA independent of RPA, facilitating ATR DDR pathway activation.

This study shows APE1 regulates the ATR-Chk1 DNA damage response by assembling biomolecular condensates in nucleoli, independent of its nuclease and redox functions.

This study analyzes APE2 genomic alterations and mRNA expression across multiple cancers using TCGA data, finding frequent mutations and upregulated expression in several cancer types.