GCAD: a Computational Framework for Mammalian Genetic Program Computer-Aided Design
Kathleen S. Dreyer, Anh V Nguyen, Gauri G. Bora, Lauren E. Redus, Hailey I. Edelstein, Jocelyn J. Garcia, Eleftheria Anastasia, Kate E. Dray, Joshua N. Leonard, Niall M. Mangan
This paper introduces a computational framework for designing mammalian genetic programs using genetic algorithms and dynamical systems models, demonstrating its ability to find optimal circuit designs and validate them experimentally.
ACS Synthetic Biology · Feb 13, 2026Peer-reviewedSynthetic Biology