Author

Kate E. Dray

Northwestern UniversityORCID 0000-0002-2972-047XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Organism:mouse· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Joshua N. LeonardiD· 4 shared Joseph J. MuldooniD· 3 shared Kathleen S. DreyeriD· 3 shared Niall M. ManganiD· 3 shared Hailey I. EdelsteiniD· 2 shared Neda BagheriiD· 2 shared Anh V NguyeniD· 1 shared Anne E. d’AquinoiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersSynthetic Biology

Joshua N. LeonardORCID

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Author profile →

4 papers

Recent·Most cited

GCAD: a Computational Framework for Mammalian Genetic Program Computer-Aided Design

Kathleen S. Dreyer, Anh V Nguyen, Gauri G. Bora, Lauren E. Redus, Hailey I. Edelstein, Jocelyn J. Garcia, Eleftheria Anastasia, Kate E. Dray, Joshua N. Leonard, Niall M. Mangan

This paper introduces a computational framework for designing mammalian genetic programs using genetic algorithms and dynamical systems models, demonstrating its ability to find optimal circuit designs and validate them experimentally.

ACS Synthetic Biology · Feb 13, 2026Peer-reviewedSynthetic Biology

Engineered Feedback Employing Natural Hypoxia-Responsive Factors Enhances Synthetic Hypoxia Biosensors

Kathleen S. Dreyer, Patrick S. Donahue, Jonathan D. Boucher, Katherine M. Chambers, Marya Y. Ornelas, Hailey I. Edelstein, Benjamin D. Leibowitz, Katherine J. Zhu, Kate E. Dray, Joseph J. Muldoon, Joshua N. Leonard

This study enhances synthetic hypoxia biosensors by integrating natural hypoxia-responsive factors and feedback circuits to improve their performance and understanding of hypoxia regulation.

ACS Synthetic Biology · May 2, 2025Peer-reviewedSynthetic Biology

Developing, characterizing and modelingCRISPR-based point-of-use pathogen diagnostics

Jaeyoung Kirsten Jung, Kathleen S. Dreyer, Kate E. Dray, Joseph J. Muldoon, Jithin D. George, Sasha Shirman, Maria D. Cabezas, Anne E. d’Aquino, Matthew S. Verosloff, Kosuke Seki, Grant A. Rybnicky, Khalid K. Alam, Neda Bagheri, Michael C. Jewett, Joshua N. Leonard, , Julius B. Lucks

The paper develops and optimizes a one-pot NASBA-Cas13a assay for rapid, sensitive detection of SARS-CoV-2 RNA without specialized equipment.

ACS Synthetic Biology · Dec 13, 2024Peer-reviewedSynthetic Biology

GAMES: A dynamic model development workflow for rigorous characterization of synthetic genetic systems

Kate E. Dray, Joseph J. Muldoon, Niall M. Mangan, Neda Bagheri, Joshua N. Leonard

The paper introduces GAMES, a workflow for developing dynamic models of synthetic genetic systems, demonstrating it with a case study on a chemically responsive transcription factor.

ACS Synthetic Biology · Jan 13, 2022Peer-reviewedSynthetic Biology