Kathleen S. Dreyer

This paper introduces a computational framework for designing mammalian genetic programs using genetic algorithms and dynamical systems models, demonstrating its ability to find optimal circuit designs and validate them experimentally.

This study enhances synthetic hypoxia biosensors by integrating natural hypoxia-responsive factors and feedback circuits to improve their performance and understanding of hypoxia regulation.

The paper develops and optimizes a one-pot NASBA-Cas13a assay for rapid, sensitive detection of SARS-CoV-2 RNA without specialized equipment.