Simulating serial-target antibacterial drug synergies using flux balance analysis
Andrew S Krueger, Christian Munck, Gautam Dantas, George M Church, James Galagan, Joseph Lehar, Morten OA Sommer
This study extends flux balance analysis to simulate drug synergies by modeling chemical inhibitors as flux diversion, showing it can predict serial target synergies in E. coli.
bioRxiv · Nov 6, 2015Systems Biology