George M Church

This paper introduces Vibrio natriegens as a new fast-growing bacterial host for genomics, providing its genome and genetic tools to enhance research efficiency.

This paper introduces daisy-chain gene drives that can alter local populations without global spread, enabling ethical use and community control.

This paper introduces a method to tune guide RNA for precise Cas9 targeting, preventing mutations in engineered organisms and demonstrating scalability and robustness across Cas9 variants and environments.

The paper constructs an ethnically relevant Korean reference genome (KOREF) to improve variant detection in Korean populations and highlights the importance of ethnic-specific assemblies for genomic research.

The paper presents extensive sequencing data from seven human genomes to serve as benchmark reference materials for improving sequencing technologies and variant calling.

This study demonstrates RNA-guided gene drives in yeast can efficiently and reversibly bias inheritance when mated to wild-type organisms.

This study extends flux balance analysis to simulate drug synergies by modeling chemical inhibitors as flux diversion, showing it can predict serial target synergies in E. coli.

This study develops a highly efficient Cas9-based transcriptional activator, VPR-Cas9, capable of activating multiple genes and promoting neuronal differentiation from iPSCs.

This paper discusses the potential of RNA-guided gene drives using CRISPR-Cas9 to alter wild populations, highlighting benefits and risks while advocating for careful assessment and public discussion.

The paper develops a framework using Fisher information to quantify spatial distinguishability of neuronal activity and applies it to neural recording methods.