Knock out of the intracellular calcium conducting ion channel Mitsugumin 23 (MG23) protects against pressure overload induced left ventricular hypertrophy and cardiac dysfunction.
Amy M Dorward, Gavin B. Robertson, Claire C. Sneddon, Richard C. Edel, Chloe L. O’Rourke, In Hwa Um, David J. Harrison, Miyuki Nishi, Hiroshi Takeshima, Colin E. Murdoch, Samantha Jane Pitt
This study shows that knocking out MG23 protects against pressure overload-induced cardiac hypertrophy and dysfunction by reducing Ca2+ leak from the sarcoplasmic reticulum.
The FASEB Journal · Jan 22, 2026Peer-reviewedPhysiology