Hiroshi Takeshima

This study shows that knocking out MG23 protects against pressure overload-induced cardiac hypertrophy and dysfunction by reducing Ca2+ leak from the sarcoplasmic reticulum.

This study shows that PDE3 inhibitors enhance bone growth by increasing Ca2+ influx through TRPM7 channels in chondrocytes, suggesting potential repositioning for short stature syndromes.

This study investigates whether MG53 interacts with the insulin receptor and affects Akt phosphorylation in muscle, heart, and liver tissues, finding low binding affinity and no effect on insulin signaling.

This study investigates Tric-b-knockout mice and finds atypical apoptotic cell death in growth plate chondrocytes due to impaired Ca2+ handling and ER stress.

This study investigates how calcium-induced calcium release via RyR3 receptors modulates the sIAHP current and its activity-dependent potentiation in hippocampal pyramidal neurons.