Connexin-36-expressing Gap Junctions in VTA GABA Neurons Sustain Opiate Dependence
Geith Maal‐Bared, Mandy Yee, Erika K. Harding, Martha Ghebreselassie, Michael Bergamini, Roxanne Choy, Ethan Hyungkeun Kim, Stephanie A. Di Vito, Maryam Patel, Mohammadreza Amirzadeh, Taryn Elizabeth Grieder, James I. Nagy, Robert P. Bonin, Derek van der Kooy
The paper shows that connexin-36 gap junctions in VTA GABA neurons are essential for opiate dependence and withdrawal, as their disruption prevents these states in rodents.
bioRxiv · Dec 18, 2020 · PreprintNeuroscience