Robert P. Bonin

Characterization of the Grin1Q536R/+ mouse: a preclinical model for GRIN1-related neurodevelopmental disorder

The paper characterizes a Grin1Q536R/+ mouse model carrying a GRIN1 variant, showing age- and sex-dependent behavioral and physiological changes linked to GRIN1-NDD.

Spinal cord Ca2+ imaging reveals glial-driven central sensitization in post-traumatic osteoarthritis

The paper develops a Ca2+ imaging pipeline to analyze spinal cord activity in pain models, identifying a glial-driven signature in post-traumatic osteoarthritis.

Metaplastic priming enables non-ionotropic NMDA receptor-mediated synaptic depotentiation in the hippocampus

This study shows that the temporal pattern of prior LTP induction affects the molecular pathways involved in depotentiation, with non-ionotropic NMDAR signaling required for compressed LTP depotentiation.

Chronic pain mediated changes in the appetitive value of affective touch in mice

This study investigates how chronic pain alters the rewarding value of gentle touch in mice by examining neural circuits and behavioral responses.

Spinal reconsolidation engages non-ionotropic NMDA receptor signaling to reverse pain hypersensitivity

This study shows that non-ionotropic NMDA receptor signaling in the spinal dorsal horn is sufficient to reverse pain hypersensitivity through reconsolidation.

Differential modulation of thermal preference after sensitization by optogenetic or pharmacological activation of heat-sensitive nociceptors

This paper develops a behavioral assay to measure thermal preference in mice after peripheral sensitization, showing that capsaicin induces cold preference and gabapentin reverses it, while optogenetic activation of central terminals does not.

Connexin-36-expressing Gap Junctions in VTA GABA Neurons Sustain Opiate Dependence

The paper shows that connexin-36 gap junctions in VTA GABA neurons are essential for opiate dependence and withdrawal, as their disruption prevents these states in rodents.

Evaluating analgesic efficacy and administration route following craniotomy in mice using the grimace scale

This study evaluates analgesic efficacy and administration routes post-craniotomy in mice using the grimace scale, finding injectable analgesics more effective than water-administered ones.