Generation, quality control, and analysis of the first genomically humanised knock-in mice for the ALS/FTD genes SOD1, TARDBP (TDP-43), and FUS
Anny Devoy, Georgia Price, Francesca De Giorgio, Rosie K. A. Bunton-Stasyshyn, David Thompson, Samanta Gasco, Alasdair J. Allan, Gemma F. Codner, R. Nair, Charlotte Tibbit, Ross McLeod, Zeinab Ali, Judith Noda, Alessandro Marrero‐Gagliardi, José Miguel Brito Armas, , Thomas J. Cunningham
The paper creates genomically humanised knock-in mice for ALS/FTD genes SOD1, TARDBP, and FUS, showing they express human proteins at endogenous levels and are phenotypically normal.
bioRxiv · Jul 5, 2021 · PreprintNeuroscience