Author

Alessandro Marrero‐Gagliardi

Universidad de La LagunaORCID 0000-0002-8470-4085Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 1 Research Focus:perturbation response prediction· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Abraham Acevedo‐ArozenaiD· 2 shared José Miguel Brito ArmasiD· 2 shared Judith NodaiD· 2 shared Matteo ZanovelloiD· 2 shared Matthew J. KeussiD· 2 shared Pietro FrattaiD· 2 shared Adrian M. IsaacsiD· 1 shared Alasdair J. AllaniD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

Abraham Acevedo‐ArozenaORCID

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Author profile →

3 papers

Recent·Most cited

U7 small nuclear RNA splice-switching therapeutics for STMN2 and UNC13A in Amyotrophic Lateral Sclerosis

Puja R. Mehta, Tomas Solomon, Sarah R. Pickles, Peter Harley, Michela Barioglio, Christoph Schweingruber, Alessandro Marrero‐Gagliardi, Yujing Gao, Francesca Mattedi, Simone Barattucci, Lilian Tsai‐Wei Lin, Eugeni M. Ryadnov, Matteo Zanovello, Alexander J. Cammack, Adrian M. Isaacs, , Marc‐David Ruepp

The paper develops U7 snRNA therapeutics to correct TDP-43-dependent mis-splicing in ALS, restoring gene expression and neuronal function in human iPSC-derived neurons.

bioRxiv · Nov 26, 2025 · PreprintNeuroscience

A functional interaction between TDP-43 and USP10 reveals USP10 dysfunction in TDP-43 proteinopathies

Alessandro Marrero‐Gagliardi, Judith Noda, Matteo Zanovello, G Gerenu, José Miguel Brito Armas, Alexander Bampton, Pascual Torres, Haizea Hernández-Eguiazu, S Moragón, F Pellegrini, C Pérez Hernández, Felipe Fumagallo-Reading, L Taoro-González, R Muñoz de Bustillo Alfaro, Anna‐Leigh Brown, , Abraham Acevedo‐Arozena

This study identifies a functional interaction between TDP-43 and USP10, showing USP10 modulates alternative splicing and can reduce TDP-43 toxicity in a mouse model of ALS and FTD.

bioRxiv · Jan 23, 2024 · PreprintNeuroscience

Generation, quality control, and analysis of the first genomically humanised knock-in mice for the ALS/FTD genes SOD1, TARDBP (TDP-43), and FUS

Anny Devoy, Georgia Price, Francesca De Giorgio, Rosie K. A. Bunton-Stasyshyn, David Thompson, Samanta Gasco, Alasdair J. Allan, Gemma F. Codner, R. Nair, Charlotte Tibbit, Ross McLeod, Zeinab Ali, Judith Noda, Alessandro Marrero‐Gagliardi, José Miguel Brito Armas, , Thomas J. Cunningham

The paper creates genomically humanised knock-in mice for ALS/FTD genes SOD1, TARDBP, and FUS, showing they express human proteins at endogenous levels and are phenotypically normal.

bioRxiv · Jul 5, 2021 · PreprintNeuroscience