Author

Charlotte Tibbit

Mary Lyon Centre at MRC Harwell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:database / resource· 1

Frequent Co-Authors

David ThompsoniD· 2 shared Elizabeth FisheriD· 2 shared Lydia TebouliD· 2 shared R. NairiD· 2 shared Ross McLeod· 2 shared Thomas J. CunninghamiD· 2 shared Abraham Acevedo‐ArozenaiD· 1 shared Adam CaulderiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersMolecular Biology

David ThompsonORCID

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2 papers

Recent·Most cited

Generation of C9orf72h370 mice, an intron 1 humanised C9orf72 repeat-expansion knock-in model

R. Nair, Mireia Carcolé, David Thompson, Charlotte Tibbit, Ross McLeod, Alexander J. Cammack, Tatiana Jakubcova, Daniel Biggs, Matthew Wyles, Matthew T Parker, Adam Caulder, Lydia Teboul, Chloe L Fisher-Ward, Ali R Awan, Michael D. Flower, , Thomas J. Cunningham

The paper generates a mouse model with a humanised C9orf72 repeat expansion to study ALS and FTD, and demonstrates a method for creating such repeat expansions in genomic sequences.

bioRxiv · Feb 6, 2025 · PreprintMolecular Biology

Generation, quality control, and analysis of the first genomically humanised knock-in mice for the ALS/FTD genes SOD1, TARDBP (TDP-43), and FUS

Anny Devoy, Georgia Price, Francesca De Giorgio, Rosie K. A. Bunton-Stasyshyn, David Thompson, Samanta Gasco, Alasdair J. Allan, Gemma F. Codner, R. Nair, Charlotte Tibbit, Ross McLeod, Zeinab Ali, Judith Noda, Alessandro Marrero‐Gagliardi, José Miguel Brito Armas, , Thomas J. Cunningham

The paper creates genomically humanised knock-in mice for ALS/FTD genes SOD1, TARDBP, and FUS, showing they express human proteins at endogenous levels and are phenotypically normal.

bioRxiv · Jul 5, 2021 · PreprintNeuroscience