Proof-of-concept of targeted degradation of p38α/β MAPK host-kinase as a potent inhibitor of coronaviruses.
Gemma Cooper, Timothy J. Snape, Maitreyi Shivkumar
This paper demonstrates that targeted degradation of p38α/β MAPK using PROTAC NR-7h potently inhibits coronavirus infection with high potency and low cytotoxicity.
bioRxiv · Apr 30, 2026 · PreprintMicrobiology