Clustering of the Adhesion-GPCR Latrophilin-3 Drives Excitatory Synapse Assembly
Chuqiao Huyan, Abrar A. Bhat, Gemma Landa, Thomas C. Südhof, Alexander R. Dunn
The paper identifies nanoscale clustering of Latrophilin-3 as a mechanism driving excitatory synapse assembly, showing that clustering, not ligand binding, is critical for synapse formation.
bioRxiv · Oct 13, 2026 · PreprintNeuroscience