Endothelial cannabinoid CB1 receptor deficiency reduces arterial inflammation and lipid uptake in response to atheroprone shear stress
Bingni Chen, Aishvaryaa Prabhu, Guo Li, Anna Cristina Kaltenbach, Yong Wang, George Shakir, Lucia Natarelli, Remco T. A. Megens, Yvonne J. F. M. Jansen, Srishti Ramanathan, Martina Geiger, Alexander Faußner, Michael Hristov, Daniel Richter, Xinyu Di, , Sabine Steffens
This paper shows that blocking endothelial CB1 receptors reduces arterial inflammation and lipid uptake under atheroprone shear stress, suggesting potential therapeutic benefits for atherosclerosis.
Nature Communications · Jul 7, 2026Peer-reviewedImmunology