Deletion of a conserved genomic region associated with adolescent idiopathic scoliosis leads to vertebral rotation in mice.
Jeremy A. McCallum-Loudeac, Edward C. Moody, Jack Williams, Georgia Johnstone, Kathleen J. Sircombe, Andrew N. Clarkson, Megan J. Wilson
This study investigates the function of a conserved genomic region linked to AIS by deleting it in mice, finding vertebral rotation and proprioceptive deficits similar to human AIS.
Human Molecular Genetics · Jan 15, 2024Peer-reviewedGenetics