Systematic chemical genomic screening of Vibrio cholerae maps gene-phenotype relationships
James R. J. Haycocks, Huda Ahmad, Micheal B. Alao, Georgia Williams, Susan Sutherland, Chris LB Graham, Laura Álvarez, Prateek Sharma, Patrick Joseph Moynihan, Felipe Cava, David C. Grainger, Danesh Moradigaravand, Manuel Banzhaf
This study uses chemical genomics to identify gene-phenotype relationships in Vibrio cholerae by screening 104 stress conditions across 3,026 single-gene mutants, revealing 1,518 significant growth phenotypes including 88 unannotated genes.
bioRxiv · Aug 19, 2026 · PreprintSystems Biology