James R. J. Haycocks

This study uses chemical genomics to identify gene-phenotype relationships in Vibrio cholerae by screening 104 stress conditions across 3,026 single-gene mutants, revealing 1,518 significant growth phenotypes including 88 unannotated genes.

The paper identifies and characterizes CisR, a small RNA that inhibits CTXφ phage production by repressing cep mRNA through Hfq-dependent base-pairing, linking phage activation to cell density and nutrient availability in V. cholerae.

ChemGenXplore provides an interactive web tool for visualizing and analyzing chemical genomic data, enabling users to explore pre-implemented and uploaded datasets with various analytical features.

This study maps CRP binding sites in EAEC to reveal its role in regulating virulence genes linked to nutritional state.

This study identifies H-NS as a transposon capture protein that directs transposition to specific chromosomal regions, affecting phenotypic diversity and gene function in bacteria.

The paper shows that prokaryotic promoters often drive divergent transcription due to symmetric elements and reciprocal stimulation between transcription start sites.

This study shows that CobB and PRPP synthase form a complex that regulates protein acetylation and deacetylation in E. coli, impacting metabolism and cellular pathways.