In vivo progressive degeneration of Huntington's disease patient-derived neurons reveals human-specific pathological phenotypes
Andrés Miguez, Sara Fernández‐García, Marta Tortajada, Georgina Bombau, Mireia Galofré, Marı́a Garcı́a-Bravo, Cristina Vila, Phil Sanders, Helena Fernández-Medina, Blanca Poquet, Cristina Salado-Manzano, Santiago Roura, Jordi Alberch, Jose Carlos Segovia, Nicholas D. Allen, , Josep Maria Canals
This study transplants HD patient-derived neurons into mice to observe in vivo degeneration and identifies mechanisms of disease propagation.
bioRxiv · Oct 21, 2020 · PreprintNeuroscience