Sara Fernández‐García

This study identifies spatially resolved aging and senescence signatures in the human hippocampus using multi-omics approaches, revealing cell-type and sex-specific gene expression changes.

This study creates a spatial and cellular atlas of the colon across age groups using spatial transcriptomics and single nucleus RNA-seq, identifying age-related molecular gradients and multicellular programs.

This study investigates how direct and indirect striatal pathways from DLS and DMS contribute to motor symptoms in HD mice, finding that these pathways are dysfunctional in HD.

This study shows that RTP801 regulates synaptic transmission and motor learning by modulating synaptic plasticity in the motor cortex.

This study transplants HD patient-derived neurons into mice to observe in vivo degeneration and identifies mechanisms of disease propagation.

This study shows that optogenetic stimulation of fronto-striatal pathways in HD mice improves motor symptoms and synaptic plasticity.