6-Methylnicotine is a strong agonist at α4β2 and α3β4 nicotinic cholinergic receptors
Thao T. Olson, Reniel Suarez Gonzalez, Yousef Aljohani, Ghazaul Dezfuli, Andrew C. Harris, Mark G. LeSage, Gerard Ahern, Kenneth J. Kellar
This study compares 6-Methylnicotine and nicotine's effects on α4β2 and α3β4 nicotinic cholinergic receptors, finding 6-MN is more potent and upregulates these receptors.
bioRxiv · Oct 16, 2026 · PreprintPharmacology & Toxicology