Sex-dependent interferon signaling drives female-biased vulnerability in Alzheimer's disease
Verónica López-López, Gerard Iniesta, Marcos Galán-Ganga, Alejandro Exposito-Coca, Aysha María Bhojwani-Cabrera, Marina Guillot-Fernández, Albert Giralt, José P. López‐Atalaya
This study identifies sex-dependent interferon signaling as a driver of female-biased Alzheimer's disease vulnerability, showing that targeting this pathway can reduce pathology and improve cognition in female mice.
bioRxiv · Aug 22, 2025 · PreprintNeuroscience