Myotube hypertrophy is associated with cancer-like metabolic reprogramming and limited by PHGDH
Lian E.M. Stadhouders, Sander A. J. Verbrugge, Jonathon A. B. Smith, Brendan M. Gabriel, Tim D. Hammersen, Detmar Kolijn, Ilse S.P. Vogel, Abdalla D. Mohamed, Gerard M.J. de Wit, Carla Offringa, Willem M.H. Hoogaars, Sebastian Gehlert, Henning Wackerhage, Richard T. Jaspers
This study shows that muscle hypertrophy involves cancer-like metabolic reprogramming, with PHGDH playing a key role in regulating myotube size through glycolytic pathways.
bioRxiv · Dec 1, 2020 · PreprintMolecular Biology