Author

Jonathon A. B. Smith

Karolinska InstitutetORCID 0000-0003-2452-1655Unclaimed ORCID profile · follow to get notified of new preprints

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Aidan J. BradyiD· 2 shared Anna KrookiD· 2 shared Brendan M. GabrieliD· 2 shared Juleen Rae ZierathiD· 2 shared Mladen SavikjiD· 2 shared Abdalla D. MohamediD· 1 shared Ahmed M. AbdelmoeziD· 1 shared Carla Offringa· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

Aidan J. BradyORCID

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3 papers

Recent·Most cited

Cell BiologyScience AdvancesPeer-reviewedJul 9, 2025

Human-specific lncRNA TMEM9B-AS1 is downregulated in skeletal muscle of individuals with type 2 diabetes and regulates ribosomal biogenesis

Ilke Sen, Jonathon A. B. Smith, Elena Caria…·Anna Krook

This study identifies TMEM9B-AS1, a human-specific lncRNA downregulated in type 2 diabetes skeletal muscle, which regulates ribosomal biogenesis by stabilizing MYC mRNA through interaction with IGF2BP1.

7 citations

humanbulk RNA-seq

Cell BiologyMolecular MetabolismPeer-reviewedJul 2, 2025

Downregulation of NR4A3 during inactivity alters glucose metabolism and impairs translation in human skeletal muscle

Jonathon A. B. Smith, Brendan M. Gabriel, Aidan J. Brady…·Nicolas J. Pillon

This study shows that reduced NR4A3 levels in skeletal muscle due to inactivity impair glucose metabolism, translation, and myotube size by affecting mTORC1 and ribosomal pathways.

11 citations

humanbulk RNA-seq

Molecular BiologybioRxivPreprintDec 1, 2020

Myotube hypertrophy is associated with cancer-like metabolic reprogramming and limited by PHGDH

Lian E.M. Stadhouders, Sander A. J. Verbrugge, Jonathon A. B. Smith…·Richard T. Jaspers

This study shows that muscle hypertrophy involves cancer-like metabolic reprogramming, with PHGDH playing a key role in regulating myotube size through glycolytic pathways.

3 citations

mousebulk RNA-seq