FGFR3 is a positive regulator of osteoblast expansion and differentiation during zebrafish skull vault development
Emilie Dambroise, Ivan Ktorza, Alessandro Brombin, Ghaith Abdessalem, Joanne Edouard, Marine Luka, Imke A.K. Fiedler, Olivia Binder, Olivier Pellé, E. Elizabeth Patton, Björn Busse, Mickaël Mathieu Ménager, Frédéric Sohm, Laurence Legeai‐Mallet
This study shows that fgfr3 loss-of-function in zebrafish causes cranial vault defects by delaying osteoblast expansion and differentiation, with changes in the extracellular matrix.
Journal of Bone and Mineral Research · May 7, 2020Peer-reviewedDevelopmental Biology