Mickaël Mathieu Ménager

Identification and Functional Characterization of Regulatory Variants in DPP9 Associated with COVID-19 Severity

The paper identifies and functionally characterizes regulatory variants in DPP9 associated with severe COVID-19 by analyzing genetic risk factors and their impact on gene expression and immune cell function.

CLONAL LYMPHOCYTE EXPANSIONS AND JAK-STAT PATHWAY MUTATIONS DEFINE A PATHOGENIC CONTINUUM DRIVING RESISTANCE TO GLUTEN-FREE DIET IN CELIAC DISEASE

This study identifies clonal lymphocyte expansions and JAK-STAT mutations in celiac disease subtypes, revealing shared mechanisms and limitations of JAK inhibitor therapy.

Sexually dimorphic interzonal crosstalk reshapes the adrenal cortex in response to pathophysiological challenges

This study shows that environmental factors like diet and dexamethasone induce sex-specific changes in adrenal cortex zones through cell lineage conversion and transcriptional reprogramming.

Induction of the ISR by AB5 subtilase cytotoxin drives IFN-I expression in pDCs via STING activation

The paper shows SubAB induces IFN-I in pDCs via STING activation and UPR, highlighting a novel mechanism of immune regulation.

Environmental and genetic drivers of population differences in SARS-CoV-2 immune responses

The paper identifies environmental and genetic factors influencing population differences in SARS-CoV-2 immune responses using single-cell RNA-sequencing data.

The Immune Factors Driving DNA Methylation Variation in Human Blood

This study identifies factors influencing DNA methylation variation in human blood, showing that cytomegalovirus infection and aging drive methylation changes, with cellular composition and DNA sequence as key predictors.

FGFR3 is a positive regulator of osteoblast expansion and differentiation during zebrafish skull vault development

This study shows that fgfr3 loss-of-function in zebrafish causes cranial vault defects by delaying osteoblast expansion and differentiation, with changes in the extracellular matrix.