Author

Gholson J Lyon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:proteomics· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1 Organism:yeast· 1

Frequent Co-Authors

Giuseppe NarzisiiD· 1 shared Han Fang· 1 shared Han FangiD· 1 shared Ivan Iossifov· 1 shared Jake Weiser· 1 shared Jason A O'Rawe· 1 shared Jason O'Rawe· 1 shared Jonathan Crain· 1 shared

Activity by Year

2014-2016 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperBioinformatics

Giuseppe NarzisiORCID

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3 papers

Recent·Most cited

Proteomic and genomic characterization of a yeast model for Ogden syndrome

Max Doerfel, Han Fang, Jonathan Crain, Michael E Klingener, Jake Weiser, Gholson J Lyon

The paper characterizes a yeast model of Ogden syndrome, showing the S37P mutation disrupts Naa10 function and affects cellular processes like chaperone activity and gene expression.

bioRxiv · Jul 12, 2016Genomics

Human genetics and clinical aspects of neurodevelopmental disorders

Gholson J Lyon, Jason O'Rawe

The paper discusses the clinical and genetic aspects of neurodevelopmental disorders, highlighting the challenges in classification and the role of de novo mutations.

bioRxiv · Oct 6, 2014 · PreprintGenetics

Accurate detection of de novo and transmitted INDELs within exome-capture data using micro-assembly

Giuseppe Narzisi, Jason A O'Rawe, Ivan Iossifov, Han Fang, Yoon-ha Lee, Zihua Wang, Yiyang Wu, Gholson J Lyon, Michael Wigler, Michael C Schatz

Scalpel detects de novo and transmitted INDELs in exome data with high specificity and sensitivity, outperforming existing tools in challenging repeat regions and identifying new autism-related genes.

Nature Methods · Aug 17, 2014Peer-reviewedBioinformatics