Spatial proximity to AD pathology defines cell-type and genotype-specific characteristics in human AD hippocampus
Christina Huan Shi, Bing Zhu, Juan Pina-Crespo, Win Ning Chen, Giau Van Vo, Huijie Huang, Kevin Y. Yip, Timothy Y. Huang
The paper analyzes spatial relationships between AD pathology and gene expression in human hippocampus using MERFISH and snRNA-seq data, identifying cell-type and genotype-specific effects of A{beta} and tau pathology.
bioRxiv · Oct 21, 2026 · PreprintNeuroscience