The paper analyzes spatial relationships between AD pathology and gene expression in human hippocampus using MERFISH and snRNA-seq data, identifying cell-type and genotype-specific effects of A{beta} and tau pathology.

bioRxiv · Oct 21, 2026 · PreprintNeuroscience

SORLA upregulation suppresses global pathological effects in aged tauopathy mouse brain

Huijie Huang, Christina Huan Shi, Wenqi Yang, Juan Piña-Crespo, Jay Bhatnagar, Julian Curatolo, Rabi Murad, Palak Mayur Shah, Alex Rosa Campos, Alexandra K Houser, Rebecca A. Porritt, Tongmei Zhang, Qiang Xiao, Shengjie Feng, Kevin Yuk-Lap Yip, Timothy Y. Huang

This study shows that increasing SORLA levels in aged tauopathy mice reduces multiple pathological effects, including tau phosphorylation, inflammation, and synaptic dysfunction.

bioRxiv · Jun 25, 2025 · PreprintNeuroscience

SUV39H1 Preserves Cancer Stem Cell Chromatin State and Properties in Glioblastoma

Chunying Li, Qiqi Xie, Sugata Ghosh, Bihui Cao, Yuanning Du, Vo Van Giau, Timothy Y. Huang, Charles Spruck, Richard L. Carpenter, Yanru Wang, Qing Richard Lu, Kenneth P. Nephew, Jia Shen

This paper shows SUV39H1 is critical for maintaining glioblastoma stem cell properties and progression, and targeting it enhances chemotherapy effectiveness.

JCI Insight · Mar 9, 2025Peer-reviewedCancer Biology

GSAP regulates mitochondrial function through the Mitochondria-associated ER membrane in the pathogenesis of Alzheimer's disease

Peng Xu, Jerry C. Chang, Xiaopu Zhou, Wei Wang, Michael A. Bamkole, Eitan Wong, Karima Bettayeb, Lu-Lin Jiang, Timothy Y. Huang, Wenjie Luo, Huaxi Xu, Angus Clark Nairn, Marc Flajolet, Nancy Y. Ip, Yue‐Ming Li, Paul Greengard

This study identifies GSAP's role in Alzheimer's disease by showing it regulates mitochondrial function through the MAM and lipid homeostasis, with a SNP linked to increased AD risk.

The Journal of Experimental Medicine · May 27, 2021Peer-reviewedNeuroscience