Author

Huijie Huang

Sanford Burnham Prebys Medical Discovery InstituteORCID 0000-0002-0713-906XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1 Assay:snRNA-seq· 1

Frequent Co-Authors

Christina Huan ShiiD· 2 shared Kevin Yuk-Lap YipiD· 2 shared Timothy Y. HuangiD· 2 shared Alex Rosa CamposiD· 1 shared Alexandra K Houser· 1 shared Bing Zhu· 1 shared Giau Van Vo· 1 shared Jay Bhatnagar· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Christina Huan ShiORCID

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2 papers

Recent·Most cited

Spatial proximity to AD pathology defines cell-type and genotype-specific characteristics in human AD hippocampus

Christina Huan Shi, Bing Zhu, Juan Pina-Crespo, Win Ning Chen, Giau Van Vo, Huijie Huang, Kevin Y. Yip, Timothy Y. Huang

The paper analyzes spatial relationships between AD pathology and gene expression in human hippocampus using MERFISH and snRNA-seq data, identifying cell-type and genotype-specific effects of A{beta} and tau pathology.

bioRxiv · Oct 21, 2026 · PreprintNeuroscience

SORLA upregulation suppresses global pathological effects in aged tauopathy mouse brain

Huijie Huang, Christina Huan Shi, Wenqi Yang, Juan Piña-Crespo, Jay Bhatnagar, Julian Curatolo, Rabi Murad, Palak Mayur Shah, Alex Rosa Campos, Alexandra K Houser, Rebecca A. Porritt, Tongmei Zhang, Qiang Xiao, Shengjie Feng, Kevin Yuk-Lap Yip, Timothy Y. Huang

This study shows that increasing SORLA levels in aged tauopathy mice reduces multiple pathological effects, including tau phosphorylation, inflammation, and synaptic dysfunction.

bioRxiv · Jun 25, 2025 · PreprintNeuroscience