Cxcl10 is required for survival during SARS-CoV-2 infection in mice
Shamik Majumdar, Joseph D. Weaver, Sergio M. Pontejo, Mahnaz Minai, Xinping Lu, Ji-Liang Gao, Gibran Holmes, Reed Johnson, Hongwei Zhang, Brian Lee Kelsall, Joshua Marion Farber, Derron A. Alves, Philip M. Murphy
This study shows that Cxcl10 deficiency in male mice increases mortality from SARS-CoV-2 infection by reducing lymphocyte infiltration in the lungs, suggesting CXCL10 is protective.
Journal of Leukocyte Biology · Nov 28, 2024Peer-reviewedImmunology